The Induction Dose of Propofol with Ketamine-Propofol and Midazolam-Propofol Co-Induction

Objective: To determine the mean induction dose of propofol with ketamine-propofol and midazolam-propofol co-induction. Methods: A total of sixty patients with American Society of Anaesthesiologist (ASA) physical status I and II, aged 20-50 years, of either sex, undergoing daycare surgeries requiring general anaesthesia were included in this study. The patients were randomly allocated into two equal groups. Group K received ketamine-propofol and group M received midazolam-propofol for induction of anaesthesia. All the patients received pethidine 0.8 mg/kg. Two minutes after the administration of co-induction agent, each patient received 20 mg of lignocaine and injection propofol was given 10 mg every five seconds until patient stopped counting and does not respond to a reminder to continue counting. The level of sedation and alertness was targeted to an observer’s assessment of alertness/ sedation score of 2. Results: Mean induction dose of propofol in the two groups was compared by student’s T test. The mean induction dose was 53.67 (30-120) mg in group K and 52.33 (30-110) mg in group M. The difference between the mean inductions doses of propofol in the two groups were statistically insignificant (P-value of 0.78). Mann Whitney test was also used to compare the mean induction doses of propofol between the two groups. The difference in mean induction doses of propofol was statistically insignificant (P-value of 0.57). Conclusion: There is no difference in the mean induction dose of propofol with ketamine-propofol and midazolampropofol co-induction. Aga Khan University Hospital, Pakistan Citation: Butt MN, Ahmed A (2013) The Induction Dose of Propofol with Ketamine-Propofol and Midazolam-Propofol Co-Induction. J Anesth Clin Res 4: 371. doi:10.4172/2155-6148.1000371